Personally I prefer the point to point soldering method. It takes longer to do initially but in the end you save time debugging because it is easier to locate connections and make changes.

A Buffered S-100 Prototype Board
One of the frustrating aspects of doing a new prototype board design is that before you can do anything useful you have to connect up all the address lines (24) , data lines (16) and numerous control line to buffers on the board.  Each requires an input line from the bus and an output line to the functional area of the board. For almost every board they will be the same.  To take the drudgery out of this a "buffered prototype S-100" board with all these connections already done. Here is a picture of the board:-


There are distinct pads for all the major buffered S-100 lines. You can start right away utilizing the board for what you had in mind.  The schematic for the board is quite simple and can be seen here.  The layout for the board can be seen here.  There are pads for a +5V, +12V and -5V or -12V voltage regulator.  The only slightly unusual thing is U108, a 74LS245 buffer that may be used to transfer data to/from the 8 bit data In/Out lines. This can sometimes be of use for interrupts in 16 bit systems. Unfortunately its on the S-100 side of bus buffers and so cannot be used for 16 bit CPU data transfers if you wanted to use this board as an 16 Bit CPU prototype board.  I have use this board for a number of S-100 prototype boards.  Here is a picture of it being used for the first PIC/RTC board:-


 
V2 of the Buffered S-100 Prototype Board.
Having utilized a number of these boards, I realized that a few little tweaks would make a big difference. A second version of the board was made.  This board has in addition to the board above:-

    1.  I/O port selection circuitry that can be jumpered for any 8 bit I/O address range.
    2.  A complete bi-directional buffer (U108) setup for 8/16 bit data transfers with 16 bit CPU's.
    3.  A dedicated 5V line across the bottom of the "patch" area for convenient hookup to IC's.
    4.  Complete flexibility as to the type or Voltage regulators used in each of the 3 positions.
 

A Production S-100 Board
Realizing that a number of people might want to utilize a board like this together with a group of people on the  Google Groups S100Computers Forum, "group purchases" are made from time to time.  Please see here for more information.