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S-100 MSDOS Compatibility Level ?

Hi All,
Im a newbie looking at getting my feet wet in my first homebrew computer. 
Just wondered what level of MSDOS Compatibility to expect for the S-100 platform ?  I'm more keen on the S-100 platform than ECB one, since I would love to play around with more advanced boards like the new 286 CPU board and 68k board. 
I've noticed theres a dedicated MSDOS Compatibility board.  I would love to run older simple DOS apps but figured better ask what to expect from overall MSDOS compatibility.   Does it support up to 6.22 without many issues or should I expect to run 3.x versions stable etc ?
Appreciate if I can get a rough idea what to expect before rushing in. :)
Many thanks